Article
Conjugation of SUMO to p85 leads to a novel mechanism of PI3K regulation.
Oncogene - 2 Jun 2016
de la Cruz-Herrera C F, Baz-Martínez M, Lang V, El Motiam A, Barbazán J, Couceiro R, Abal M, Vidal A, Esteban M, Muñoz-Fontela C, Nieto A, Rodríguez M S, Collado M, Rivas C
Abstract excerpt
Class IA phosphatidylinositol 3-kinases (PI3Ks) are composed of p110 catalytic and p85 regulatory subunits. How regulatory subunits modulate PI3K activity remains only partially understood. Here we identified SUMO (small ubiquitin-related modifier) as a new player modulating this regulation. We demonstrate that both p85β and p85α are conjugated to SUMO1 and SUMO2. We identified two lysine residues located at the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.