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Article

Critical roles of the guanylyl cyclase B receptor in endochondral ossification and development of female reproductive organs.

Proceedings of the National Academy of Sciences of the United States of America - 7 Dec 2004

Tamura Naohisa, Doolittle Lynda K, Hammer Robert E, Shelton John M, Richardson James A, Garbers David L

Abstract excerpt

Guanylyl cyclase B is the receptor for a small peptide (C-type natriuretic peptide) produced locally in many different tissues. To unravel the functions of the receptor, we generated mice lacking guanylyl cyclase B through gene targeting. Expression of the receptor mRNA in tissues such as bone and female reproductive organs was evident, and significant phenotypes associated with each of these tissues were...

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Identifiers

PMID: 15572448
DOI: 10.1073/pnas.0407894101
PMCID: PMC534612

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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