Article
The Local CNP/GC-B system in growth plate is responsible for physiological endochondral bone growth.
Scientific reports - 27 May 2015
Nakao Kazumasa, Osawa Kenji, Yasoda Akihiro, Yamanaka Shigeki, Fujii Toshihito, Kondo Eri, Koyama Noriaki, Kanamoto Naotetsu, Miura Masako, Kuwahara Koichiro, Akiyama Haruhiko, Bessho Kazuhisa, Nakao Kazuwa
Abstract excerpt
Recent studies revealed C-type natriuretic peptide (CNP) and its receptor, guanylyl cyclase-B (GC-B) are potent stimulators of endochondral bone growth. As they exist ubiquitously in body, we investigated the physiological role of the local CNP/GC-B in the growth plate on bone growth using cartilage-specific knockout mice. Bones were severely shorter in cartilage-specific CNP or GC-B knockout mice and the extent...
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