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Article

Core Binding Factor β Expression in Ovarian Granulosa Cells Is Essential for Female Fertility

15 Mar 2018

Abstract excerpt

Core binding factor β (CBFβ) is a non-DNA-binding partner of all RUNX proteins and critical for transcription activity of CBF transcription factors (RUNXs/CBFβ). In the ovary, the expression of Runx1 and Runx2 is highly induced by the luteinizing hormone (LH) surge in ovulatory follicles, whereas Cbfb is constitutively expressed. To investigate the physiological significance of CBFs in the ovary, the current...

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PMID: 29554271
DOI: 10.1210/en.2018-00011

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