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Article

Generation and reproductive phenotypes of mice lacking estrogen receptor beta.

Proceedings of the National Academy of Sciences of the United States of America - 22 Dec 1998

Krege J H, Hodgin J B, Couse J F, Enmark E, Warner M, Mahler J F, Sar M, Korach K S, Gustafsson J A, Smithies O

Abstract excerpt

Estrogens influence the differentiation and maintenance of reproductive tissues and affect lipid metabolism and bone remodeling. Two estrogen receptors (ERs) have been identified to date, ERalpha and ERbeta. We previously generated and studied knockout mice lacking estrogen receptor alpha and reported severe reproductive and behavioral phenotypes including complete infertility of both male and female mice and...

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Identifiers

PMID: 9861029
DOI: 10.1073/pnas.95.26.15677
PMCID: PMC28103

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