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Article

[Hormones and osteoporosis update. Effects of natriuretic peptides on endochondral bone growth].

Clinical calcium - 1 Jul 2009

Yasoda Akihiro, Nakao Kazuwa

Abstract excerpt

We revealed that the C-type natriuretic peptide (CNP) and its receptor guanylyl cyclase-B (GC-B) system is a potent and physiological stimulator of endochondral bone growth by using transgenic and knockout mice. In humans, one form of skeletal dysplasias, acromesomelic dysplasia, type Maroteaux, was reported to be caused by loss of function mutations in the GC-B gene. Further studies are needed for clarifying the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19567998
DOI: CliCa090710031008

Genes

CNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Hormones and osteoporosis update. Effects of natriuretic peptides on endochondral bone growth].PMID 19567998Read ↗

Translational research of C-type natriuretic peptide (CNP) into skeletal dysplasias.Semantic proximity Read ↗

[Genetic basis for skeletal disease. CNP therapy for achondroplasia].Semantic proximity Read ↗

Mutations in the transmembrane natriuretic peptide receptor NPR-B impair skeletal growth and cause acromesomelic dysplasia, type Maroteaux.Semantic proximity Read ↗

Role of the natriuretic peptide system in normal growth and growth disorders.Semantic proximity Read ↗

The Local CNP/GC-B system in growth plate is responsible for physiological endochondral bone growth.Semantic proximity Read ↗

CNP, the Third Natriuretic Peptide: Its Biology and Significance to the Cardiovascular SystemSemantic proximity Read ↗

Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway.Semantic proximity Read ↗

Molecular and in silico analyses validates pathogenicity of homozygous mutations in the NPR2 gene underlying variable phenotypes of Acromesomelic dysplasia, type Maroteaux.Semantic proximity Read ↗

Systemic Administration of C-Type Natriuretic Peptide as a Novel Therapeutic Strategy for Skeletal DysplasiasSemantic proximity Read ↗

Dwarfism and early death in mice lacking C-type natriuretic peptideSemantic proximity Read ↗

[Clinical condition and therapy of bone diseases].Semantic proximity Read ↗

Significance of C-type natriuretic peptide (CNP) in endochondral ossification: analysis of CNP knockout mice.Semantic proximity Read ↗

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