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Article

Translational research of C-type natriuretic peptide (CNP) into skeletal dysplasias.

Endocrine journal - 1 Jan 2010

Yasoda Akihiro, Nakao Kazuwa

Abstract excerpt

By using transgenic and knockout mice, we have elucidated that C-type natriuretic peptide (CNP) is a potent stimulator of endochondral bone growth. In humans, loss-of-function mutations in the gene coding for guanylyl cyclase-B (GC-B), the specific receptor for CNP, have been proved to be the cause of acromesomelic dysplasia, type Maroteaux, one form of human skeletal dysplasias. Following these results, we have...

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Share to Achondroplasia
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Atrial Natriuretic Factor

Source

Identifiers

PMID: 20567091
DOI: 10.1507/endocrj.k10e-164

Genes

CNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Translational research of C-type natriuretic peptide (CNP) into skeletal dysplasias.PMID 20567091Read ↗

[Genetic basis for skeletal disease. CNP therapy for achondroplasia].Semantic proximity Read ↗

[Hormones and osteoporosis update. Effects of natriuretic peptides on endochondral bone growth].Semantic proximity Read ↗

Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway.Semantic proximity Read ↗

Mutations in the transmembrane natriuretic peptide receptor NPR-B impair skeletal growth and cause acromesomelic dysplasia, type Maroteaux.Semantic proximity Read ↗

Role of the natriuretic peptide system in normal growth and growth disorders.Semantic proximity Read ↗

Systemic Administration of C-Type Natriuretic Peptide as a Novel Therapeutic Strategy for Skeletal DysplasiasSemantic proximity Read ↗

Dwarfism and early death in mice lacking C-type natriuretic peptideSemantic proximity Read ↗

An Overgrowth Disorder Associated with Excessive Production of cGMP Due to a Gain-of-Function Mutation of the Natriuretic Peptide Receptor 2 GeneSemantic proximity Read ↗

Evaluation of the therapeutic potential of a CNP analog in a Fgfr3 mouse model recapitulating achondroplasia.Semantic proximity Read ↗

Molecular and in silico analyses validates pathogenicity of homozygous mutations in the NPR2 gene underlying variable phenotypes of Acromesomelic dysplasia, type Maroteaux.Semantic proximity Read ↗

The Local CNP/GC-B system in growth plate is responsible for physiological endochondral bone growth.Semantic proximity Read ↗

Significance of C-type natriuretic peptide (CNP) in endochondral ossification: analysis of CNP knockout mice.Semantic proximity Read ↗

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