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Article

[Genetic basis for skeletal disease. CNP therapy for achondroplasia].

Clinical calcium - 1 Aug 2010

Yasoda Akihiro, Nakao Kazuwa

Abstract excerpt

By using transgenic and knockout mice, we have elucidated that C-type natriuretic peptide (CNP) is a potent stimulator of endochondral bone growth. Furthermore, loss-of-function mutations in the gene coding for guanylyl cyclase-B (GC-B) , the specific receptor for CNP, have been proved to cause impaired skeletal growth in humans. Following these results, we have started to translate the stimulatory effect of CNP...

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Source

Identifiers

PMID: 20675932
DOI: CliCa100812121218

Genes

CNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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[Genetic basis for skeletal disease. CNP therapy for achondroplasia].PMID 20675932Read ↗

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The Local CNP/GC-B system in growth plate is responsible for physiological endochondral bone growth.Semantic proximity Read ↗

An Overgrowth Disorder Associated with Excessive Production of cGMP Due to a Gain-of-Function Mutation of the Natriuretic Peptide Receptor 2 GeneSemantic proximity Read ↗

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