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Article

Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomes.

Journal of cell science - 15 Dec 2004

Gibbs Daniel, Azarian Sassan M, Lillo Concepcion, Kitamoto Junko, Klomp Adriana E, Steel Karen P, Libby Richard T, Williams David S

Abstract excerpt

Myosin VIIa functions in the outer retina, and loss of this function causes human blindness in Usher syndrome type 1B (USH1B). In mice with mutant Myo7a, melanosomes in the retinal pigmented epithelium (RPE) are distributed abnormally. In this investigation we detected many proteins in RPE cells that could potentially participate in melanosome transport, but of those tested, only myosin VIIa and Rab27a were found...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15572405
DOI: 10.1242/jcs.01580
PMCID: PMC2942070

Genes

RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomes.PMID 15572405Read ↗

Analysis of the linkage of MYRIP and MYO7A to melanosomes by RAB27A in retinal pigment epithelial cells.Semantic proximity Read ↗

The many different cellular functions of MYO7A in the retina.Semantic proximity Read ↗

A novel allele of myosin VIIa reveals a critical function for the C-terminal FERM domain for melanosome transport in retinal pigment epithelial cells.Semantic proximity Read ↗

Rab27a enables myosin Va-dependent melanosome capture by recruiting the myosin to the organelle.Semantic proximity Read ↗

Identification of an organelle receptor for myosin-Va.Semantic proximity Read ↗

Melanophilin, the product of the leaden locus, is required for targeting of myosin-Va to melanosomes.Semantic proximity Read ↗

Rab27a regulates the peripheral distribution of melanosomes in melanocytes.Semantic proximity Read ↗

Knockdown of myosin Va isoforms by RNAi as a tool to block melanosome transport in primary human melanocytes.Semantic proximity Read ↗

Rab8 regulates the actin-based movement of melanosomes.Semantic proximity Read ↗

The leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytes.Semantic proximity Read ↗

Retinal pigment epithelium defects in humans and mice with mutations in MYO7A: imaging melanosome-specific autofluorescence.Semantic proximity Read ↗

More than just a cargo adapter, melanophilin prolongs and slows processive runs of myosin Va.Semantic proximity Read ↗

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