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Article

Rab27a enables myosin Va-dependent melanosome capture by recruiting the myosin to the organelle.

Journal of cell science - 1 Mar 2001

Wu X, Rao K, Bowers M B, Copeland N G, Jenkins N A, Hammer J A

Abstract excerpt

The peripheral accumulation of melanosomes characteristic of wild-type mouse melanocytes is driven by a cooperative process involving long-range, bidirectional, microtubule-dependent movements coupled to capture and local movement in the actin-rich periphery by myosin Va, the product of the dilute locus. Genetic evidence suggests that Rab27a, the product of the ashen locus, functions with myosin Va in this...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11228153
DOI: 10.1242/jcs.114.6.1091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rab27a enables myosin Va-dependent melanosome capture by recruiting the myosin to the organelle.PMID 11228153Read ↗

Melanophilin, the product of the leaden locus, is required for targeting of myosin-Va to melanosomes.Semantic proximity Read ↗

The leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytes.Semantic proximity Read ↗

Rab27a regulates the peripheral distribution of melanosomes in melanocytes.Semantic proximity Read ↗

Identification of an organelle receptor for myosin-Va.Semantic proximity Read ↗

Expression of constructs of the neuronal isoform of myosin-Va interferes with the distribution of melanosomes and other vesicles in melanoma cells.Semantic proximity Read ↗

Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomes.Semantic proximity Read ↗

Analysis of the linkage of MYRIP and MYO7A to melanosomes by RAB27A in retinal pigment epithelial cells.Semantic proximity Read ↗

More than just a cargo adapter, melanophilin prolongs and slows processive runs of myosin Va.Semantic proximity Read ↗

Knockdown of myosin Va isoforms by RNAi as a tool to block melanosome transport in primary human melanocytes.Semantic proximity Read ↗

A mutation in <i>Rab27a</i> causes the vesicle transport defects observed in <i>ashen</i> miceSemantic proximity Read ↗

A tissue-specific exon of myosin Va is responsible for selective cargo binding in melanocytes.Semantic proximity Read ↗

A novel allele of myosin VIIa reveals a critical function for the C-terminal FERM domain for melanosome transport in retinal pigment epithelial cells.Semantic proximity Read ↗

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