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Article

Melanophilin, the product of the leaden locus, is required for targeting of myosin-Va to melanosomes.

Traffic (Copenhagen, Denmark) - 1 Feb 2002

Provance D William, James Ted L, Mercer John A

Abstract excerpt

The formation of complex subcellular organelles requires the coordinated targeting of multiple components. Melanosome biogenesis in mouse melanocytes is an excellent model system for studying the coordinated function of multiple gene products in intracellular trafficking. To begin to order events...

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Topics

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Share to Adaptor Proteins, Signal Transducing
Share to Fluorescent Antibody Technique, Indirect
Share to Melanosomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microscopy, Fluorescence

Share to Myosin Heavy Chains

Share to Myosin Type V

Share to rab GTP-Binding Proteins

Share to rab27 GTP-Binding Proteins

Source

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Identifiers

PMID: 11929602
DOI: 10.1034/j.1600-0854.2002.030205.x
PMCID: PMC1351229

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11929602-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Melanophilin, the product of the leaden locus, is required for targeting of myosin-Va to melanosomes.PMID 11929602Read ↗

The leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytes.Semantic proximity Read ↗

Rab27a enables myosin Va-dependent melanosome capture by recruiting the myosin to the organelle.Semantic proximity Read ↗

Rab27a regulates the peripheral distribution of melanosomes in melanocytes.Semantic proximity Read ↗

Missense mutations in the globular tail of myosin-Va indilutemice partially impair binding of Slac2-a/melanophilinSemantic proximity Read ↗

A mutation in <i>Rab27a</i> causes the vesicle transport defects observed in <i>ashen</i> miceSemantic proximity Read ↗

Mutations in Mlph, encoding a member of the Rab effector family, cause the melanosome transport defects observed in leaden mice.Semantic proximity Read ↗

Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomes.Semantic proximity Read ↗

Analysis of the linkage of MYRIP and MYO7A to melanosomes by RAB27A in retinal pigment epithelial cells.Semantic proximity Read ↗

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Griscelli syndrome: a model system to study vesicular trafficking.Semantic proximity Read ↗

Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport.Semantic proximity Read ↗

Rab27A-binding protein Slp2-a is required for peripheral melanosome distribution and elongated cell shape in melanocytes.Semantic proximity Read ↗

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