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Article

Identification of an organelle receptor for myosin-Va.

Nature cell biology - 1 Apr 2002

Wu Xufeng S, Rao Kang, Zhang Hong, Wang Fei, Sellers James R, Matesic Lydia E, Copeland Neal G, Jenkins Nancy A, Hammer John A

Abstract excerpt

Little is known about how molecular motors bind to their vesicular cargo. Here we show that myosin-Va, an actin-based vesicle motor, binds to one of its cargoes, the melanosome, by interacting with a receptor-protein complex containing Rab27a and melanophilin, a postulated Rab27a effector. Rab27a binds to the melanosome first and then recruits melanophilin, which in turn recruits myosin-Va. Melanophilin creates...

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Identifiers

PMID: 11887186
DOI: 10.1038/ncb760

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of an organelle receptor for myosin-Va.PMID 11887186Read ↗

Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport.Semantic proximity Read ↗

Rab27a enables myosin Va-dependent melanosome capture by recruiting the myosin to the organelle.Semantic proximity Read ↗

More than just a cargo adapter, melanophilin prolongs and slows processive runs of myosin Va.Semantic proximity Read ↗

A tissue-specific exon of myosin Va is responsible for selective cargo binding in melanocytes.Semantic proximity Read ↗

Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomes.Semantic proximity Read ↗

The leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytes.Semantic proximity Read ↗

Rab27a regulates the peripheral distribution of melanosomes in melanocytes.Semantic proximity Read ↗

Analysis of the linkage of MYRIP and MYO7A to melanosomes by RAB27A in retinal pigment epithelial cells.Semantic proximity Read ↗

A role for Na+,K+-ATPase α1 in regulating Rab27a localisation on melanosomes.Semantic proximity Read ↗

The actin-binding domain of Slac2-a/melanophilin is required for melanosome distribution in melanocytes.Semantic proximity Read ↗

Knockdown of myosin Va isoforms by RNAi as a tool to block melanosome transport in primary human melanocytes.Semantic proximity Read ↗

The roles of Rab27 and its effectors in the regulated secretory pathways.Semantic proximity Read ↗

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