Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The many different cellular functions of MYO7A in the retina.

Biochemical Society transactions - 1 Oct 2011

Williams David S, Lopes Vanda S

Abstract excerpt

Mutations in MYO7A (myosin VIIa) cause Usher syndrome type 1B, a disorder involving profound congenital deafness and progressive blindness. In the retina, most MYO7A is localized in the apical region of the RPE (retinal pigmented epithelial) cells, and a small amount is associated with the ciliary and periciliary membranes of the photoreceptor cells. Its roles appear to be quite varied. Studies with MYO7A-null...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Melanosomes
Share to Mice, Knockout
Share to Myosin VIIa

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myosins

Share to Photoreceptor Cells

Share to Retina

Share to Retinal Pigment Epithelium

Share to Usher Syndromes

Source

Open in PubMed Open full text

Identifiers

PMID: 21936790
DOI: 10.1042/BST0391207
PMCID: PMC3703834

Genes

RPE
RPE65

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The many different cellular functions of MYO7A in the retina.PMID 21936790Read ↗

Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomes.Semantic proximity Read ↗

The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65Semantic proximity Read ↗

Usher syndrome: animal models, retinal function of Usher proteins, and prospects for gene therapy.Semantic proximity Read ↗

Analysis of the linkage of MYRIP and MYO7A to melanosomes by RAB27A in retinal pigment epithelial cells.Semantic proximity Read ↗

A novel allele of myosin VIIa reveals a critical function for the C-terminal FERM domain for melanosome transport in retinal pigment epithelial cells.Semantic proximity Read ↗

Human Usher 1B/mouse shaker-1: the retinal phenotype discrepancy explained by the presence/absence of myosin VIIA in the photoreceptor cells.Semantic proximity Read ↗

Loss of ciliary proteins IFT20 and IFT88 results in defective phagocytosis and metabolism in the RPESemantic proximity Read ↗

Spata7 is a retinal ciliopathy gene critical for correct RPGRIP1 localization and protein trafficking in the retinaSemantic proximity Read ↗

Rhodopsin Trafficking and Mistrafficking: Signals, Molecular Components, and Mechanisms.Semantic proximity Read ↗

Loss of Motor Protein MYO1C Causes Rhodopsin Mislocalization and Results in Impaired Visual Function.Semantic proximity Read ↗

Gene Supplementation of <i>MYO7A</i> or activation of <i>Myo7b</i> for treatment of Usher syndrome 1BSemantic proximity Read ↗

Megalin deficiency perturbs retinal homeostasis and impairs cathepsin D processing and phagosome-lysosome maturation in the retinal pigment epitheliumSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.