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Article

More than just a cargo adapter, melanophilin prolongs and slows processive runs of myosin Va.

The Journal of biological chemistry - 11 Oct 2013

Sckolnick Maria, Krementsova Elena B, Warshaw David M, Trybus Kathleen M

Abstract excerpt

Myosin Va (myoVa) is a molecular motor that processively transports cargo along actin tracks. One well studied cargo in vivo is the melanosome, a pigment organelle that is moved first by kinesin on microtubules and then handed off to myoVa for transport in the actin-rich dendritic periphery of melanocytes. Melanophilin (Mlph) is the adapter protein that links Rab27a-melanosomes to myoVa. Using total internal...

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Identifiers

PMID: 23979131
DOI: 10.1074/jbc.M113.476929
PMCID: PMC3795233

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More than just a cargo adapter, melanophilin prolongs and slows processive runs of myosin Va.PMID 23979131Read ↗

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