Article
The leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytes.
Traffic (Copenhagen, Denmark) - 1 Mar 2002
Hume Alistair N, Collinson Lucy M, Hopkins Colin R, Strom Molly, Barral Duarte C, Bossi Giovanna, Griffiths Gillian M, Seabra Miguel C
Abstract excerpt
The function of lysosome-related organelles such as melanosomes in melanocytes, and lytic granules in cytotoxic T lymphocytes is disrupted in Griscelli syndrome and related diseases. Griscelli syndrome results from loss of function mutations in either the RAB27A (type 1 Griscelli syndrome) or MYO5A (type 2 Griscelli syndrome) genes. Melanocytes from Griscelli syndrome patients and respective murine models ashen...
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