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Article

Knockdown of myosin Va isoforms by RNAi as a tool to block melanosome transport in primary human melanocytes.

The Journal of investigative dermatology - 1 Oct 2008

Van Gele Mireille, Geusens Barbara, Schmitt Anne-Marie, Aguilar Luc, Lambert Jo

Abstract excerpt

The movement of melanosomes, dense melanin-containing organelles, within human melanocytes is actin-dependent and mediated through the formation of a Rab27a-Slac2-a-myosin Va (MyoVa) protein complex. We previously showed that only the melanocyte-specific exon F isoforms of MyoVa are involved in melanosome transport to the dendrite extremities. Here, we investigate siRNA to downregulate the exon F-containing...

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Share to Epidermal Cells
Share to Melanocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Melanosomes

Share to Myosin Heavy Chains

Share to Myosin Type V

Share to rab GTP-Binding Proteins

Share to rab27 GTP-Binding Proteins

Share to Transduction, Genetic

Source

Identifiers

PMID: 18401430
DOI: 10.1038/jid.2008.100

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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