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Article

A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 7 Dec 2004

Gao Hui, Ouyang Xuesong, Banach-Petrosky Whitney, Borowsky Alexander D, Lin Yong, Kim Minjung, Lee Hansol, Shih Weichung-Joseph, Cardiff Robert D, Shen Michael M, Abate-Shen Cory

Abstract excerpt

In human prostate cancer, the frequent down-regulation of p27(kip1) protein expression is correlated with poor clinical outcome, yet p27(kip1) rarely undergoes mutational inactivation. Here, we investigate the consequences of reducing or eliminating p27(kip1) function for prostate carcinogenesis in the context of a mouse modeling lacking the Nkx3.1 homeobox gene and the Pten tumor suppressor. Unexpectedly, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15569926
DOI: 10.1073/pnas.0407693101
PMCID: PMC535400

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis.PMID 15569926Read ↗

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