Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An unusual gene dosage effect of p27kip1 in a mouse model of prostate cancer.

Cell cycle (Georgetown, Tex.) - 1 Mar 2005

Abate-Shen Cory, Shen Michael M

Abstract excerpt

Expression of the p27kip1 cell cycle inhibitor is downregulated in a wide range of carcinomas, yet it is rarely inactivated completely. Our recent studies of a mouse model of prostate carcinogenesis have revealed that cancer progression is enhanced by a two-fold reduction in p27kip1 gene dosage, but is unexpectedly inhibited by further decrease in p27kip1 activity. This paradoxical finding may explain the unusual...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to Cyclin D1
Share to Cyclin-Dependent Kinase Inhibitor p27

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Progression

Share to Down-Regulation

Share to Gene Dosage

Share to Gene Expression Regulation, Neoplastic

Share to Prostatic Neoplasms

Source

Identifiers

PMID: 15701964

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An unusual gene dosage effect of p27kip1 in a mouse model of prostate cancer.PMID 15701964Read ↗

A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis.Semantic proximity Read ↗

Pten dose dictates cancer progression in the prostate.Semantic proximity Read ↗

Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype.Semantic proximity Read ↗

[P27Kip1 is certainly a suppressor gene but with a dose effect].Semantic proximity Read ↗

Genetic manipulation of LKB1 elicits lethal metastatic prostate cancerSemantic proximity Read ↗

A mouse model of heterogeneous, c-MYC-initiated prostate cancer with loss of Pten and p53.Semantic proximity Read ↗

Brca1 inactivation induces p27(Kip1)-dependent cell cycle arrest and delayed development in the mouse mammary gland.Semantic proximity Read ↗

Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer.Semantic proximity Read ↗

Loss of p27kip1 increases genomic instability and induces radio-resistance in luminal breast cancer cells.Semantic proximity Read ↗

Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cellsSemantic proximity Read ↗

Identification of oncogenes collaborating with p27 <sup>Kip1</sup> loss by insertional mutagenesis and high-throughput insertion site analysisSemantic proximity Read ↗

The p27Kip1 tumor suppressor gene: Still a suspect or proven guilty?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.