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Article

Interaction of Nkx3.1 and p27kip1 in prostate tumor initiation.

The American journal of pathology - 1 May 2004

Gary Bernard, Azuero Ricardo, Mohanty Gayatree S, Bell Walter C, Eltoum Isam-Eldin A, Abdulkadir Sarki A

Abstract excerpt

The homeodomain transcription factor Nkx3.1 and the cyclin-dependent kinase inhibitor p27kip1 have both been implicated in prostate tumor suppression. In addition, both of these molecules demonstrate haploinsufficiency for tumor suppression, in which loss of a single allele is sufficient to lead to the development of preneoplastic or neoplastic lesions. We have generated mice carrying compound mutant alleles of...

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Source

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Identifiers

PMID: 15111307
DOI: 10.1016/S0002-9440(10)63719-4
PMCID: PMC1615644

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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