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Article

Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastases.

Cancer research - 15 Jul 2003

Abate-Shen Cory, Banach-Petrosky Whitney A, Sun Xiaohui, Economides Kyriakos D, Desai Nishita, Gregg Jeffery P, Borowsky Alexander D, Cardiff Robert D, Shen Michael M

Abstract excerpt

Recent studies have shown that several loss-of-function mouse models of prostate carcinogenesis can develop a spectrum of precancerous lesions that resemble human prostatic intraepithelial neoplasia (PIN). Here, we have investigated the malignant potential of the high-grade PIN lesions that form in Nkx3.1(+/-); Pten(+/-) compound mutant mice and demonstrate their neoplastic progression in a serial...

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PMID: 12873978

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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