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Article

Genetic mosaics reveal both cell-autonomous and cell-nonautonomous function of murine p27Kip1.

Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 2006

Chien Wei-Ming, Rabin Stuart, Macias Everardo, Miliani de Marval Paula L, Garrison Kendra, Orthel Jason, Rodriguez-Puebla Marcelo, Fero Matthew L

Abstract excerpt

Loss of the cyclin-dependent kinase inhibitor p27(Kip1) leads to an overall increase in animal growth, pituitary tumors, and hyperplasia of hematopoietic organs, yet it is unknown whether all cells function autonomously in response to p27(Kip1) activity or whether certain cells take cues from their neighbors. In addition, there is currently no genetic evidence that tumor suppression by p27(Kip1) is...

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Identifiers

PMID: 16537495
DOI: 10.1073/pnas.0509514103
PMCID: PMC1449657

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Genetic mosaics reveal both cell-autonomous and cell-nonautonomous function of murine p27Kip1.PMID 16537495Read ↗

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors.Semantic proximity Read ↗

Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype.Semantic proximity Read ↗

Cyclin-dependent kinase inhibitor p27(Kip1) is required for mouse mammary gland morphogenesis and function.Semantic proximity Read ↗

Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).Semantic proximity Read ↗

Combined loss of p21(waf1/cip1) and p27(kip1) enhances tumorigenesis in mice.Semantic proximity Read ↗

Genetic evidence for the interactions of cyclin D1 and p27(Kip1) in mice.Semantic proximity Read ↗

A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis.Semantic proximity Read ↗

Genetic characterization of p27(kip1) and stathmin in controlling cell proliferation in vivo.Semantic proximity Read ↗

Deletion of the p27Kip1 gene restores normal development in cyclin D1-deficient mice.Semantic proximity Read ↗

Brca1 inactivation induces p27(Kip1)-dependent cell cycle arrest and delayed development in the mouse mammary gland.Semantic proximity Read ↗

Functional Collaboration between Different Cyclin-Dependent Kinase Inhibitors Suppresses Tumor Growth with Distinct Tissue SpecificitySemantic proximity Read ↗

Identification of oncogenes collaborating with p27 <sup>Kip1</sup> loss by insertional mutagenesis and high-throughput insertion site analysisSemantic proximity Read ↗

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