Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Caenorhabditis elegans UNC-14 RUN domain protein binds to the kinesin-1 and UNC-16 complex and regulates synaptic vesicle localization.

Molecular biology of the cell - 1 Feb 2005

Sakamoto Rie, Byrd Dana T, Brown Heather M, Hisamoto Naoki, Matsumoto Kunihiro, Jin Yishi

Abstract excerpt

Kinesin-1 is a heterotetramer composed of kinesin heavy chain (KHC) and kinesin light chain (KLC). The Caenorhabditis elegans genome has a single KHC, encoded by the unc-116 gene, and two KLCs, encoded by the klc-1 and klc-2 genes. We show here that UNC-116/KHC and KLC-2 form a complex orthologous to conventional kinesin-1. KLC-2 also binds UNC-16, the C. elegans JIP3/JSAP1 JNK-signaling scaffold protein, and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fluorescent Antibody Technique, Indirect
Share to Genes, Helminth

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kinesins

Share to Precipitin Tests

Share to Synaptic Vesicles

Share to Transgenes

Share to Two-Hybrid System Techniques

Share to Vesicular Transport Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 15563606
DOI: 10.1091/mbc.e04-07-0553
PMCID: PMC545882

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Caenorhabditis elegans UNC-14 RUN domain protein binds to the kinesin-1 and UNC-16 complex and regulates synaptic vesicle localization.PMID 15563606Read ↗

UNC-16, a JNK-signaling scaffold protein, regulates vesicle transport in C. elegans.Semantic proximity Read ↗

Kinesin-1 acts with netrin and DCC to maintain sensory neuron position in Caenorhabditis elegans.Semantic proximity Read ↗

The role of kinesin-1 in neuronal dense core vesicle transport, locomotion and lifespan regulation in C. elegans.Semantic proximity Read ↗

The kinesin-associated protein UNC-76 is required for axonal transport in the Drosophila nervous system.Semantic proximity Read ↗

Phosphorylation-regulated axonal dependent transport of syntaxin 1 is mediated by a Kinesin-1 adapter.Semantic proximity Read ↗

Regulatory machinery of UNC-33 Ce-CRMP localization in neurites during neuronal development in Caenorhabditis elegans.Semantic proximity Read ↗

Scaffold protein JSAP1 is transported to growth cones of neurites independent of JNK signaling pathways in PC12h cells.Semantic proximity Read ↗

The doublecortin-related gene zyg-8 is a microtubule organizer in Caenorhabditis elegans neurons.Semantic proximity Read ↗

CRMP/UNC-33 organizes microtubule bundles for KIF5-mediated mitochondrial distribution to axon.Semantic proximity Read ↗

Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans.Semantic proximity Read ↗

Genome-wide analysis reveals pathways important for the development and maturation of excitatory synaptic connections to GABAergic neurons.Semantic proximity Read ↗

UNC-18 promotes both the anterograde trafficking and synaptic function of syntaxin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.