Article
Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.
Proceedings of the National Academy of Sciences of the United States of America - 24 Nov 1998
Starr R, Metcalf D, Elefanty A G, Brysha M, Willson T A, Nicola N A, Hilton D J, Alexander W S
Abstract excerpt
SOCS-1, a member of the suppressor of cytokine signaling (SOCS) family, was identified in a genetic screen for inhibitors of interleukin 6 signal transduction. SOCS-1 transcription is induced by cytokines, and the protein binds and inhibits Janus kinases and reduces cytokine-stimulated tyrosine p...
Topics
- Abnormalities, Multiple
- Aging
- Animals
- Bone Marrow Cells
- Carrier Proteins
- Enzyme Inhibitors
- Hematocrit
- Interleukin-6
- Leukocyte Count
- Liver
- Lymphocytes
- Lymphoid Tissue
- Mice
- Mice, Knockout
- Phenotype