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Article

SOCS2 is the critical regulator of GH action in murine growth plate chondrogenesis.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 May 2012

Pass Chloe, MacRae Vicky Elizabeth, Huesa Carmen, Faisal Ahmed S, Farquharson Colin

Abstract excerpt

Suppressor of Cytokine Signaling-2 (SOCS2) is a negative regulator of growth hormone (GH) signaling and bone growth via inhibition of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway. This has been classically demonstrated by the overgrowth phenotype of SOCS2(-/-) mice, which has normal systemic insulin-like growth factor 1 (IGF-1) levels. The local effects of GH on bone...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22228213
DOI: 10.1002/jbmr.1544

Genes

SOCS2
SOCS1
SOCS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SOCS2 is the critical regulator of GH action in murine growth plate chondrogenesis.PMID 22228213Read ↗

Biological Evidence That SOCS-2 Can Act Either as an Enhancer or Suppressor of Growth Hormone SignalingSemantic proximity Read ↗

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Lack of Socs2 expression causes the high-growth phenotype in mice.Semantic proximity Read ↗

Suppressor of cytokine signaling-2 deficiency induces molecular and metabolic changes that partially overlap with growth hormone-dependent effects.Semantic proximity Read ↗

Negative Regulation of Growth Hormone Receptor SignalingSemantic proximity Read ↗

JAK2-IGF1 axis in osteoclasts regulates postnatal growth in mice.Semantic proximity Read ↗

STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2.Semantic proximity Read ↗

Physiology and pathophysiology of the growth plate.Semantic proximity Read ↗

In Vivo Targeting of the Growth Hormone Receptor (GHR) Box1 Sequence Demonstrates that the GHR Does Not Signal Exclusively through JAK2Semantic proximity Read ↗

Systemic Jak1 activation causes extrarenal calcitriol production and skeletal alterations provoking stunted growth.Semantic proximity Read ↗

gp130/STAT3 signaling is required for homeostatic proliferation and anabolism in postnatal growth plate and articular chondrocytesSemantic proximity Read ↗

Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth PlateSemantic proximity Read ↗

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