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Article

Loss of signal transducer and activator of transcription 5 leads to hepatosteatosis and impaired liver regeneration†

19 Jul 2007

Abstract excerpt

UNLABELLED: Growth hormone controls many facets of a cell's biology through the transcription factors Stat5a and Stat5b (Stat5). However, whole body deletion of these genes from the mouse does not provide portentous information on cell-specific cytokine signaling. To explore liver-specific functions of Stat5, the entire Stat5 locus was deleted in hepatocytes using Cre-mediated recombination. Notably, Stat5-mutant...

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Share to Cytokine Signaling Pathways and Interactions
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Identifiers

PMID: 17640041
DOI: 10.1002/hep.21713

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Loss of signal transducer and activator of transcription 5 leads to hepatosteatosis and impaired liver regeneration†PMID 17640041Read ↗

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