Article
Lack of Socs2 expression causes the high-growth phenotype in mice.
Genomics - 1 Mar 2001
Horvat S, Medrano J F
Abstract excerpt
Characterizing causal molecular defects in mouse models of overgrowth or dwarfism helps to identify the key genes and pathways that regulate the growth process. We report here the molecular basis for high growth (hg), a spontaneous mutation that causes a 30-50% increase in postnatal growth. We conclude that hg is an allele of the suppressor of cytokine signaling 2 (Socs2), a member of a family of regulators of...
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