Article
The insulin gene variable number tandem repeat and risk of type 2 diabetes in a population-based sample of families and unrelated men and women.
The Journal of clinical endocrinology and metabolism - 1 Feb 2005
Meigs James B, Dupuis Josée, Herbert Alan G, Liu Chunyu, Wilson Peter W F, Cupples L Adrienne
Abstract excerpt
Abnormalities in insulin regulation are central to the pathogenesis of type 2 diabetes. We assessed variation in the insulin gene variable number tandem repeat (INS VNTR) minisatellite (using the -23Hph1 A/T single nucleotide polymorphism) as a risk factor for 92 cases of incident type 2 diabetes in 883 unrelated Framingham Heart Study (FHS) subjects and in a separate sample of 698 members of 282 FHS nuclear...
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