Localization of a type I diabetes susceptibility locus to the variable tandem repeat region flanking the insulin gene.

doi:10.2337/diab.42.12.1708

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Article

Localization of a type I diabetes susceptibility locus to the variable tandem repeat region flanking the insulin gene.

Diabetes - 1 Dec 1993

Owerbach D, Gabbay K H

Abstract excerpt

A susceptibility gene for type I diabetes is present on chromosome 11p15.5, but its location, identity, and mechanism of action are unknown. We have sequenced 14 kilobases of DNA flanking the human insulin gene and found new DNA polymorphisms and determined their frequencies in the general popula...

Topics

Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 11
DNA
DNA Primers
Diabetes Mellitus, Type 1
Family
Genetic Predisposition to Disease
Genotype
Haplotypes
Humans
Insulin
Molecular Sequence Data
Polymerase Chain Reaction
Polymorphism, Genetic
Repetitive Sequences, Nucleic Acid

Source

Open in PubMed

Identifiers

PMID: 8243816
DOI: 10.2337/diab.42.12.1708

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8243816-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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