Article
The variable number of tandem repeats upstream of the insulin gene is a susceptibility locus for latent autoimmune diabetes in adults.
Diabetes - 1 Jun 2006
Desai Minal, Zeggini Eleftheria, Horton Virginia A, Owen Katharine R, Hattersley Andrew T, Levy Jonathan C, Hitman Graham A, Walker Mark, Holman Rury R, McCarthy Mark I, Clark Anne
Abstract excerpt
The etiopathological relationship between latent autoimmune diabetes in adults (LADA) and classical type 1 (insulin dependent) diabetes remains unclear. Variation at the insulin gene variable number of tandem repeats (VNTR) minisatellite influences susceptibility to type 1 diabetes, but studies in LADA have been small and inconsistent. We examined the role of insulin gene variation (using flanking variants as...
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