Human type 1 diabetes and the insulin gene: principles of mapping polygenes.

doi:10.1146/annurev.genet.30.1.343

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Article

Human type 1 diabetes and the insulin gene: principles of mapping polygenes.

Annual review of genetics - 1 Jan 1996

Bennett S T, Todd J A

Abstract excerpt

We review the strategy used to identify a susceptibility locus (IDDM2) for type 1 (insulin dependent) diabetes mellitus. As type 1 diabetes is becoming the paradigm for dissecting multifactorial disease genetics, the approach described provides important general guidelines for positional cloning...

Topics

Alleles
Chromosome Mapping
Diabetes Mellitus, Type 1
Genetic Variation
Genomic Imprinting
Humans
Minisatellite Repeats

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