Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inositol diphosphate signaling regulates telomere length.

The Journal of biological chemistry - 11 Feb 2005

York Sally J, Armbruster Blaine N, Greenwell Patricia, Petes Thomas D, York John D

Abstract excerpt

Activation of phospholipase C-dependent inositol polyphosphate signaling pathways generates distinct messengers derived from inositol 1,4,5-trisphosphate that control gene expression and mRNA export. Here we report the regulation of telomere length by production of a diphosphorylinositol tetrakisphosphate, PP-IP4, synthesized by the KCS1 gene product. Loss of PP-IP4 production results in lengthening of telomeres,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ataxia Telangiectasia Mutated Proteins
Share to Blotting, Southern

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrolysis

Share to Inositol Phosphates

Share to Open Reading Frames

Share to Phosphotransferases (Phosphate Group Acceptor)

Share to Telomere

Share to Type C Phospholipases

Source

Identifiers

PMID: 15561716
DOI: 10.1074/jbc.M412070200

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inositol diphosphate signaling regulates telomere length.PMID 15561716Read ↗

Replication stress conferred by POT1 dysfunction promotes telomere relocalization to the nuclear pore.Semantic proximity Read ↗

Kinase-independent functions of TEL1 in telomere maintenance.Semantic proximity Read ↗

RAD51AP1 Is an Essential Mediator of Alternative Lengthening of TelomeresSemantic proximity Read ↗

C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae.Semantic proximity Read ↗

ATM function and telomere stability.Semantic proximity Read ↗

Protein kinase C controls activation of the DNA integrity checkpoint.Semantic proximity Read ↗

Tel2 regulates the stability of PI3K-related protein kinases.Semantic proximity Read ↗

Telomere-independent Rap1 is an IKK adaptor and regulates NF-κB-dependent gene expressionSemantic proximity Read ↗

A protein-counting mechanism for telomere length regulation in yeast.Semantic proximity Read ↗

Pot1 inactivation leads to rampant telomere resection and loss in one cell cycle.Semantic proximity Read ↗

TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene.Semantic proximity Read ↗

Plc1p is required for proper chromatin structure and activity of the kinetochore in Saccharomyces cerevisiae by facilitating recruitment of the RSC complex.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.