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Article

Plc1p is required for proper chromatin structure and activity of the kinetochore in Saccharomyces cerevisiae by facilitating recruitment of the RSC complex.

Molecular genetics and genomics : MGG - 1 May 2009

Desai Parima, Guha Nilanjan, Galdieri Luciano, Hadi Sara, Vancura Ales

Abstract excerpt

High-fidelity chromosome segregation during mitosis requires kinetochores, protein complexes that assemble on centromeric DNA and mediate chromosome attachment to spindle microtubules. In budding yeast, phosphoinositide-specific phospholipase C (Plc1p encoded by PLC1 gene) is important for function of kinetochores. Deletion of PLC1 results in alterations in chromatin structure of centromeres, reduced binding of...

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PMID: 19205744
DOI: 10.1007/s00438-009-0427-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Plc1p is required for proper chromatin structure and activity of the kinetochore in Saccharomyces cerevisiae by facilitating recruitment of the RSC complex.PMID 19205744Read ↗

Genetic evidence for a role of phospholipase C at the budding yeast kinetochore.Semantic proximity Read ↗

A mutation in PLC1, a candidate phosphoinositide-specific phospholipase C gene from Saccharomyces cerevisiae, causes aberrant mitotic chromosome segregation.Semantic proximity Read ↗

The yeast RSC chromatin-remodeling complex is required for kinetochore function in chromosome segregation.Semantic proximity Read ↗

A mutation in NPS1/STH1, an essential gene encoding a component of a novel chromatin-remodeling complex RSC, alters the chromatin structure of Saccharomyces cerevisiae centromeres.Semantic proximity Read ↗

Analysis of kinesin motor function at budding yeast kinetochores.Semantic proximity Read ↗

Polo kinase recruitment via the constitutive centromere-associated network at the kinetochore elevates centromeric RNA.Semantic proximity Read ↗

Chromatin assembly factor I and Hir proteins contribute to building functional kinetochores in S. cerevisiae.Semantic proximity Read ↗

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Interactions between the kinetochore complex and the protein kinase A pathway in Saccharomyces cerevisiae.Semantic proximity Read ↗

Yeast phospholipase C is required for normal acetyl-CoA homeostasis and global histone acetylation.Semantic proximity Read ↗

NudC is required for Plk1 targeting to the kinetochore and chromosome congression.Semantic proximity Read ↗

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