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Article

New joint covariance- and marginal-based tests for association and linkage for quantitative traits for random and non-random sampling.

Genetic epidemiology - 1 Jan 2005

Tiwari Hemant K, Holt Janet, George Varghese, Beasley T Mark, Amos Christopher I, Allison David B

Abstract excerpt

We develop novel statistical tests for transmission disequilibrium testing (tests of linkage in the presence of association) for quantitative traits using parents and offspring. These joint tests utilize information in both the covariance (or more generally, dependency) between genotype and phenotype and the marginal distribution of genotype. Using computer simulation we test the validity (Type I error rate...

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PMID: 15558568
DOI: 10.1002/gepi.20035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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