A generalized test of genotype-phenotype causality in population-sampled nuclear families.

Abstract excerpt

We recently developed a causal inference framework and test-the Transmission Mean Test (TMT)-to identify causal genotype-phenotype relationships in population-sampled parent-child trios, where one child per family is observed. Here, we establish the generalized TMT (gTMT) for population-sampled nuclear families, allowing multiple offspring per family. This extension focuses on detecting genetic loci with non-zero...

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