Robust transmission regression models for linkage and association.

Abstract excerpt

We present a general regression model that accounts for both linkage and linkage disequilibrium (LD) when analyzing nuclear family data. The method does not require LD to exist in order to evaluate linkage, but if LD does exist, the power to detect linkage can increase due to improved information on linkage phase. The proposed method is general, allowing for a variety of traits (e.g., binary affection status,...

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