Article
Extreme heterogeneity in the molecular events leading to the establishment of chiasmata during meiosis i in human oocytes.
American journal of human genetics - 1 Jan 2005
Lenzi Michelle L, Smith Jenetta, Snowden Timothy, Kim Mimi, Fishel Richard, Poulos Bradford K, Cohen Paula E
Abstract excerpt
In humans, ~50% of conceptuses are chromosomally aneuploid as a consequence of errors in meiosis, and most of these aneuploid conceptuses result in spontaneous miscarriage. Of these aneuploidy events, 70% originate during maternal meiosis, with the majority proposed to arise as a direct result of defective crossing over during meiotic recombination in prophase I. By contrast, <1%-2% of mouse germ cells exhibit...
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