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Crossover Interference, Crossover Maturation, and Human Aneuploidy

19 Aug 2019

Abstract excerpt

A striking feature of human female sexual reproduction is the high level of gametes that exhibit an aberrant number of chromosomes (aneuploidy). A high baseline observed in women of prime reproductive age is followed by a dramatic increase in older women. Proper chromosome segregation requires one or more DNA crossovers (COs) between homologous maternal and paternal chromosomes, in combination with cohesion...

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PMID: 31424607
DOI: 10.1002/bies.201800221

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