Article

<i>MLH1/3</i> variants causing aneuploidy, pregnancy loss, and premature reproductive aging

2021-01-14

Abstract excerpt

Most spontaneous pregnancy losses are a result of embryonic aneuploidy stemming from mis-segregation of chromosomes during meiosis. Proper disjunction of homologous chromosomes is dependent upon precise control of crossing-over, a process requiring the mismatch repair (MMR) genes MLH1 and MLH3 . Both are required for fertility and completion of meiosis in mice. People inheriting variants in these genes are often...

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Literature Corpus work: a6e7a019-775c-5940-a398-3fc09656ae6a
DOI: 10.1101/2021.01.14.426654

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