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Meiotic Recombination in Human Oocytes

18 Sept 2009

Abstract excerpt

Studies of human trisomies indicate a remarkable relationship between abnormal meiotic recombination and subsequent nondisjunction at maternal meiosis I or II. Specifically, failure to recombine or recombination events located either too near to or too far from the centromere have been linked to the origin of human trisomies. It should be possible to identify these abnormal crossover configurations by using...

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PMID: 19763179
DOI: 10.1371/journal.pgen.1000661

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