The meiotic defects of mutants in the Drosophila mps1 gene reveal a critical role of Mps1 in the segregation of achiasmate homologs.

doi:10.1016/j.cub.2005.02.062

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Article

The meiotic defects of mutants in the Drosophila mps1 gene reveal a critical role of Mps1 in the segregation of achiasmate homologs.

Current biology : CB - 12 Apr 2005

Gilliland William D, Wayson Sarah M, Hawley R Scott

Abstract excerpt

The conserved kinase Mps1 is necessary for the proper functioning of the mitotic and meiotic spindle checkpoints (MSCs), which monitor the integrity of the spindle apparatus and prevent cells from progressing into anaphase until chromosomes are properly aligned on the metaphase plate. In Drosophila melanogaster, a null allele of the gene encoding Mps1 was recently shown to be required for the proper functioning...

Topics

Animals
Cell Cycle Proteins
Chromosome Segregation
Cytogenetic Analysis
Drosophila Proteins
Drosophila melanogaster
Female
Indoles
Meiosis
Mutation
Protein Kinases
Protein Serine-Threonine Kinases

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Open in PubMed

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PMID: 15823541
DOI: 10.1016/j.cub.2005.02.062

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