Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting the Mitotic Checkpoint to Kill Tumor Cells

16 Dec 2010

Abstract excerpt

One of the most common hallmarks of cancer cells is aneuploidy or an abnormal number of chromosomes. This abnormal chromosome content is a consequence of chromosome missegregation during mitosis, a defect that is seen more frequently in tumor cell divisions as in normal cell divisions. In fact, a large fraction of human tumors display a chromosome instable phenotype, meaning that they very frequently missegregate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Genomics and Chromatin Dynamics
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21475725
DOI: 10.1007/s12672-010-0059-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting the Mitotic Checkpoint to Kill Tumor CellsPMID 21475725Read ↗

Chemical Genetic Inhibition of Mps1 in Stable Human Cell Lines Reveals Novel Aspects of Mps1 Function in MitosisSemantic proximity Read ↗

Chromosomal Instability by Inefficient Mps1 Auto-Activation Due to a Weakened Mitotic Checkpoint and Lagging ChromosomesSemantic proximity Read ↗

Targeting the Mitotic Checkpoint for Cancer Therapy with NMS-P715, an Inhibitor of MPS1 KinaseSemantic proximity Read ↗

On the road to cancer: aneuploidy and the mitotic checkpoint.Semantic proximity Read ↗

TC Mps1 12, a novel Mps1 inhibitor, suppresses the growth of hepatocellular carcinoma cells via the accumulation of chromosomal instabilitySemantic proximity Read ↗

Mps1 expression is critical for chromosome orientation and segregation in yeast with high ploidySemantic proximity Read ↗

Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1.Semantic proximity Read ↗

Plk1 Inhibition Causes Post-Mitotic DNA Damage and Senescence in a Range of Human Tumor Cell LinesSemantic proximity Read ↗

Selective vulnerability of aneuploid human cancer cells to inhibition of the spindle assembly checkpointSemantic proximity Read ↗

Mitotic checkpoint defects in human cancers and their implications to chemotherapySemantic proximity Read ↗

Effects of the Selective MPS1 Inhibitor MPS1-IN-3 on Glioblastoma Sensitivity to Antimitotic DrugsSemantic proximity Read ↗

FOXM1 is critical for the fitness recovery of chromosomally unstable cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.