A genetic switch for epilepsy in adult mice.

doi:10.1523/JNEUROSCI.4579-03.2004

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Article

A genetic switch for epilepsy in adult mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 17 Nov 2004

Krestel Heinz E, Shimshek Derya R, Jensen Vidar, Nevian Thomas, Kim Jinhyun, Geng Yu, Bast Thomas, Depaulis Antoine, Schonig Kai, Schwenk Frieder, Bujard Hermann, Hvalby Øivind, Sprengel Rolf, Seeburg Peter H

Abstract excerpt

Premature death from seizures afflicts gene-targeted mice expressing the Q/R site-unedited glutamate receptor subunit GluR-B(Q) of AMPA receptors in central neurons. Early seizure-related death has now been circumvented by a genetic switch that restricts GluR-B(Q) expression to forebrain principal neurons from postnatal stages onward, prominently in hippocampus and striatum and less so in cortex and amygdala....

Topics

Action Potentials
Animals
Calcium
Electroencephalography
Epilepsy
Female
Hippocampus
Integrases
Male
Mice
Mice, Transgenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurons

Phenotype

Prosencephalon

Pyramidal Cells

Receptors, AMPA

Synaptic Transmission

Transgenes

Source

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Identifiers

PMID: 15548671
DOI: 10.1523/JNEUROSCI.4579-03.2004
PMCID: PMC6730297

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