Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neurological dysfunctions in mice expressing different levels of the Q/R site-unedited AMPAR subunit GluR-B.

Nature neuroscience - 1 Jan 1999

Feldmeyer D, Kask K, Brusa R, Kornau H C, Kolhekar R, Rozov A, Burnashev N, Jensen V, Hvalby O, Sprengel R, Seeburg P H

Abstract excerpt

We generated mouse mutants with targeted AMPA receptor (AMPAR) GluR-B subunit alleles, functionally expressed at different levels and deficient in Q/R-site editing. All mutant lines had increased AMPAR calcium permeabilities in pyramidal neurons, and one showed elevated macroscopic conductances of these channels. The AMPAR-mediated calcium influx induced NMDA-receptor-independent long-term potentiation (LTP) in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium
Share to Electric Conductivity

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hippocampus

Share to Long-Term Potentiation

Share to Nervous System Diseases

Share to Neural Pathways

Share to Receptors, AMPA

Share to Receptors, Glutamate

Source

Identifiers

PMID: 10195181
DOI: 10.1038/4561

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neurological dysfunctions in mice expressing different levels of the Q/R site-unedited AMPAR subunit GluR-B.PMID 10195181Read ↗

The AMPA receptor subunit GluR-B in its Q/R site-unedited form is not essential for brain development and function.Semantic proximity Read ↗

A genetic switch for epilepsy in adult mice.Semantic proximity Read ↗

Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-B allele in mice.Semantic proximity Read ↗

The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer’s diseaseSemantic proximity Read ↗

Mechanisms of disease: motoneuron disease aggravated by transgenic expression of a functionally modified AMPA receptor subunit.Semantic proximity Read ↗

Enhanced odor discrimination and impaired olfactory memory by spatially controlled switch of AMPA receptors.Semantic proximity Read ↗

Context-dependent NMDA receptor dysfunction predicts seizure treatment in mice with human GluN1 variantSemantic proximity Read ↗

Mice with genetically modified NMDA and AMPA receptors.Semantic proximity Read ↗

Common synaptic phenotypes arising from diverse mutations in the human NMDA receptor subunit GluN2A.Semantic proximity Read ↗

Common synaptic phenotypes arising from diverse mutations in the human NMDA receptor subunit GluN2ASemantic proximity Read ↗

Phenotype of mice carrying an NMDA receptor GluN2B protein-truncating variant associated with intellectual disabilitySemantic proximity Read ↗

The pathogenic S688Y mutation in the ligand-binding domain of the GluN1 subunit regulates the properties of NMDA receptors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.