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Article

Neurological dysfunctions in mice expressing different levels of the Q/R site-unedited AMPAR subunit GluR-B.

Nature neuroscience - 1 Jan 1999

Feldmeyer D, Kask K, Brusa R, Kornau H C, Kolhekar R, Rozov A, Burnashev N, Jensen V, Hvalby O, Sprengel R, Seeburg P H

Abstract excerpt

We generated mouse mutants with targeted AMPA receptor (AMPAR) GluR-B subunit alleles, functionally expressed at different levels and deficient in Q/R-site editing. All mutant lines had increased AMPAR calcium permeabilities in pyramidal neurons, and one showed elevated macroscopic conductances o...

Topics

Alleles
Animals
Brain
Calcium
Electric Conductivity
Gene Expression
Hippocampus
Long-Term Potentiation
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nervous System Diseases

Neural Pathways

Phenotype

Receptors, AMPA

Receptors, Glutamate

Source

Identifiers

PMID: 10195181
DOI: 10.1038/4561

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-10195181-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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