Article
Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-B allele in mice.
Science (New York, N.Y.) - 8 Dec 1995
Brusa R, Zimmermann F, Koh D S, Feldmeyer D, Gass P, Seeburg P H, Sprengel R
Abstract excerpt
The arginine residue at position 586 of the GluR-B subunit renders heteromeric alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-sensitive glutamate receptor channels impermeable to calcium. The codon for this arginine is introduced at the precursor messenger RNA (pre-mRNA) stage by site-selective adenosine editing of a glutamine codon. Heterozygous mice engineered by gene targeting to harbor an...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.