Article
The AMPA receptor subunit GluR-B in its Q/R site-unedited form is not essential for brain development and function.
Proceedings of the National Academy of Sciences of the United States of America - 10 Nov 1998
Kask K, Zamanillo D, Rozov A, Burnashev N, Sprengel R, Seeburg P H
Abstract excerpt
Calcium permeability of L-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) in excitatory neurons of the mammalian brain is prevented by coassembly of the GluR-B subunit, which carries an arginine (R) residue at a critical site of the channel pore. The codon for this arginin...
Topics
- Animals
- Brain
- Calcium
- Female
- Gene Expression Regulation, Developmental
- Ion Transport
- Male
- Mice
- Mutation
- Receptors, AMPA
- Receptors, Glutamate
- Signal Transduction