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Article

Severity of atypical absence phenotype in GABAB transgenic mice is subunit specific.

Epilepsy & behavior : E&B - 1 Apr 2009

Stewart Lee S, Wu Ying, Eubanks James H, Han Hua, Leschenko Yevgen, Perez Velazquez Jose L, Cortez Miguel A, Snead O Carter

Abstract excerpt

Overexpression of GABA(B)R1a receptors in mice (R1a(+)) results in an atypical absence seizure phenotype characterized by 3- to 6-Hz slow spike-and-wave discharges (SSWDs), reduced synaptic plasticity, and cognitive impairment. Here we tested the hypothesis that increased R1 expression causes atypical absence epilepsy and is not subunit specific. GABA(B)R1b receptors were overexpressed in mouse forebrain (R1b(+))...

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Source

Identifiers

PMID: 19435582
DOI: 10.1016/j.yebeh.2009.01.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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