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Article

A spontaneous mutation involving Kcnq2 (Kv7.2) reduces M-current density and spike frequency adaptation in mouse CA1 neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Feb 2006

Otto James F, Yang Yan, Frankel Wayne N, White H Steve, Wilcox Karen S

Abstract excerpt

The M-type K+ current [IK(M)] activates in response to membrane depolarization and regulates neuronal excitability. Mutations in two subunits (KCNQ2 and KCNQ3; Kv7.2 and Kv7.3) that underlie the M-channel cause the human seizure disorder benign familial neonatal convulsions (BFNC), presumably by reducing IK(M) function. In mice, the Szt1 mutation, which deletes the genomic DNA encoding the KCNQ2 C terminus and...

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Source

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Identifiers

PMID: 16481438
DOI: 10.1523/JNEUROSCI.1575-05.2006
PMCID: PMC6674924

Genes

KCNQ2
KCNQ3
CHRNA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A spontaneous mutation involving Kcnq2 (Kv7.2) reduces M-current density and spike frequency adaptation in mouse CA1 neurons.PMID 16481438Read ↗

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