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Regulation of Iron Transport inStreptococcus pneumoniaeby RitR, an Orphan Response Regulator

16 Nov 2004

Abstract excerpt

RitR (formerly RR489) is an orphan two-component signal transduction response regulator in Streptococcus pneumoniae that has been shown to be required for lung pathogenicity. In the present study, by using the rough strain R800, inactivation of the orphan response regulator gene ritR by allele replacement reduced pathogenicity in a cyclophosphamide-treated mouse lung model but not in a thigh model, suggesting a...

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PMID: 15547286
DOI: 10.1128/jb.186.23.8123-8136.2004

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