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Article

Roles of <i>rel</i><sub><i>Spn</i></sub> in stringent response, global regulation and virulence of serotype 2 <i>Streptococcus pneumoniae</i> D39

25 Mar 2009

Abstract excerpt

RelA/SpoT homologue (RSH) proteins have (p)ppGpp synthetase and hydrolase activities that mediate major global responses to nutrient limitation and other stresses. RSH proteins are conserved in most bacteria and play diverse roles in bacterial pathogenesis. We report here that the RSH protein of Streptococcus pneumoniae, Rel(Spn), can be deleted and is the primary source of (p)ppGpp synthesis in virulent strain...

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PMID: 19426208
DOI: 10.1111/j.1365-2958.2009.06669.x

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