Identification of the genes directly controlled by the response regulator CiaR in <i>Streptococcus pneumoniae</i>: five out of 15 promoters drive expression of small non‐coding RNAs

Abstract excerpt

The two-component regulatory system CiaRH of Streptococcus pneumoniae has been implicated in beta-lactam resistance, maintenance of cell integrity, competence and virulence, but the genes that are regulated directly by the system have not been defined. Using transcriptional mapping, in vitro CiaR binding, and in vivo analysis of CiaR-mediated regulation, 15 promoters were identified to be directly controlled by...

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